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  3. UroRenal, Vascular
Please use this identifier to cite or link to this item: http://hdl.handle.net/11434/2013
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dc.contributor.authorLawrentschuk, Nathan-
dc.contributor.authorHeriot, Alexander-
dc.contributor.otherTeh, Jiasian-
dc.contributor.otherO'Connor, Ellen-
dc.contributor.otherO'Brien, Jonathan-
dc.contributor.otherLim, Wei Mou-
dc.contributor.otherTaylor, Michael-
dc.contributor.otherRamsay, Robert-
dc.date.accessioned2021-07-30T03:26:42Z-
dc.date.available2021-07-30T03:26:42Z-
dc.date.issued2020-10-
dc.identifier.citationFuture Oncol . 2020 Oct;16(29):2357-2369en_US
dc.identifier.issn1744-8301en_US
dc.identifier.issn1479-6694en_US
dc.identifier.urihttp://hdl.handle.net/11434/2013-
dc.description.abstractPenile squamous cell carcinoma (SCC) is a rare and aggressive urological malignancy. Advanced penile SCC requires multimodal management, including surgery and systemic therapy. Given its rarity, there have been few substantial advances in our understanding of the molecular and genomic drivers of penile SCC, especially for patients with relapsed or advanced disease. In this review, we discuss the molecular and genomic landscape of penile SCC, clinical trials in progress and implications for novel therapeutic targets. Future work should focus on preclinical models to provide a platform for investigation and validation of new molecular pathways for testing of therapeutics.en_US
dc.publisherFuture Medicineen_US
dc.subjectImmunotherapyen_US
dc.subjectPathogenesisen_US
dc.subjectPenile Canceren_US
dc.subjectSolid Tumoren_US
dc.subjectSquamous Cell Carcinomaen_US
dc.subjectCancer Services Clinical Institute, Epworth HealthCare, Victoria, Australiaen_US
dc.subjectUrology and Vascular Clinical Institute, Epworth HealthCare, Victoria, Australiaen_US
dc.titleFuture directions in advanced penile cancer - mechanisms of carcinogenesis and a search for targeted therapy.en_US
dc.typeJournal Articleen_US
dc.identifier.doi10.2217/fon-2020-0434en_US
dc.identifier.journaltitleFuture Oncologyen_US
dc.description.pubmeduripubmed.ncbi.nlm.nih.gov/32713198/en_US
dc.description.affiliatesDivision of Cancer Surgery, Peter MacCallum Centre, Melbourne, Victoria, Australia.en_US
dc.description.affiliatesUniversity of Melbourne, Department of Surgery, Austin Hospital, Melbourne, Victoria, Australia.en_US
dc.description.affiliatesDepartment of Surgery, University of Melbourne & Royal Melbourne Hospital, Department of Urology, Melbourne, Victoria, Australia.en_US
dc.description.affiliatesSir Peter MacCallum Dept. of Oncology, University of Melbourne, Melbourne, Victoria, Australia.en_US
dc.type.studyortrialReviewen_US
dc.type.contenttypeTexten_US
Appears in Collections:UroRenal, Vascular

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