Amyloid-β and tau imaging in chronic traumatic brain injury: a cross-sectional study.

Abstract

Aims: 1.to assess amyloid-β and tau burden in long-term TBI survivors and healthy controls using PET imaging. 2. to examine PET data in relation to time since injury and age at injury. TBI has been increasingly promoted as a risk factor for Alzheimer’s disease. Evidence of amyloid-β and tau beyond the initial years post injury is inconclusive. There is conflicting evidence from PET, CSF and post-mortem studies of elevated amyloid-β and tau pathology in chronic TBI survivors compared to controls. The relationships between amyloid-β and tau pathology and injury characteristics, such as time since injury and age at injury, are also unclear.