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dc.contributor.authorHoldsworth-Carson, Sarah-
dc.contributor.otherRao, Sushma-
dc.contributor.otherBoughton, Berin-
dc.contributor.otherSnel, Marten-
dc.contributor.otherPukala, Tara-
dc.contributor.otherGriffiths, Meaghan-
dc.contributor.otherRogers, Peter-
dc.contributor.otherGirling, Jane-
dc.description.abstractBackground and Aim: Endometriosis diagnosis requires surgical visualisation of lesions and histopathology. To date, no non-invasive diagnostic test has been validated. Discovery research using sensitive high-throughput mass spectrometry (MS) has the potential to improve identification of clinically-relevant plasma proteins.The aim of this study was to undertake MS-based proteomic biomarker discovery using minimally-invasive plasma specimens from patients with and without endometriosis.Conclusions: High-throughput MS-based proteomic biomarker discovery successfully identified 470 proteins in an endometriosis cohort. Case-control analysis revealed significantly different protein expression profiles in association with endometriosis. Further validation in an independent sample set is underway. Biomarker discovery using plasma proteomics offers a minimally invasive approach to endometriosis diagnosis.en_US
dc.subjectMass Spectrometryen_US
dc.subjectProteomic Biomarkeren_US
dc.subjectPlasma Proteinsen_US
dc.subject. Julia Argyrou Endometriosis Centre, Epworth HealthCare, Victoria, Australiaen_US
dc.titlePlasma mass spectrometry-based proteomic biomarker discovery for endometriosis.en_US
dc.typeConference Posteren_US
dc.description.affiliatesSouth Australian Health and Medical Research Institute, Adelaide, SA, Australiaen_US
dc.description.affiliatesAdelaide Medical School, University of Adelaide, Adelaide, SA, Australiaen_US
dc.description.affiliatesAustralian National Phenome Centre, Harry Perkins Institute of Medical Research, Murdoch, WA, Australiaen_US
dc.description.affiliatesSchool of Physical Sciences, University of Adelaide, Adelaide, SA, Australiaen_US
dc.description.affiliatesDepartment of Obstetrics and Gynaecology, University of Melbourne and Gynaecology Research Centre, Royal Women’s Hospital, Parkville, VIC, Australiaen_US
dc.description.affiliatesDepartment of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New Zealanden_US
dc.type.studyortrialCase Control Studiesen_US
dc.description.conferencenameEpworth HealthCare Research Month 2023en_US
dc.description.conferencelocationEpworth Research Institute, Victoria, Australiaen_US
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