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Please use this identifier to cite or link to this item: http://hdl.handle.net/11434/295
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dc.contributor.authorHovens, Christopheren
dc.contributor.otherAtkins, Ryanen
dc.contributor.otherNg, Wayneen
dc.contributor.otherStylli, Stanleyen
dc.contributor.otherKaye, Andrewen
dc.date2014-11en
dc.date.accessioned2015-07-27T23:29:00Zen
dc.date.available2015-07-27T23:29:00Zen
dc.date.issued2015-01en
dc.identifier.citationJ Clin Neurosci. 2015 Jan;22(1):14-20en
dc.identifier.issn0967-5868en
dc.identifier.urihttp://hdl.handle.net/11434/295en
dc.description.abstractGlioblastoma multiforme (GBM) is a malignant and incurable glial brain tumour. The current best treatment for GBM includes maximal safe surgical resection followed by concomitant radiotherapy and adjuvant temozolomide. Despite this, median survival is still only 14-16 months. Mechanisms that lead to chemo- and radio-resistance underpin treatment failure. Insights into the DNA repair mechanisms that permit resistance to chemoradiotherapy in GBM may help improve patient responses to currently available therapies.en
dc.publisherElsevieren
dc.relation.urihttp://www.sciencedirect.com/science/article/pii/S0967586814005670-
dc.subjectAustralian Prostate Cancer Research Centre at Epworth, Richmond, VIC, Australia.en
dc.subjectGlioblastoma Multiformeen
dc.subjectGBMen
dc.subjectGlial Brain Tumouren
dc.subjectBase Excision Repairen
dc.subjectGlioma Resistanceen
dc.subjectMGMTen
dc.subjectPARPen
dc.subjectTemozolomide Chemotherapyen
dc.titleRepair mechanisms help glioblastoma resist treatment.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of Clinical Neuroscienceen
dc.description.pubmedurihttp://www.ncbi.nlm.nih.gov/pubmed/25444993en
dc.description.affiliatesDepartment of Surgery, The University of Melbourne, The Royal Melbourne Hospital, Grattan Street, Parkville, VIC 3050, Australiaen
dc.description.affiliatesDepartment of Neurosurgery, The Royal Melbourne Hospital, Parkville, VIC, Australia.en
dc.type.contenttypeTexten
Appears in Collections:Cancer Services
Epworth Prostate Centre
Neurosciences

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