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http://hdl.handle.net/11434/295| Title: | Repair mechanisms help glioblastoma resist treatment. |
| Epworth Authors: | Hovens, Christopher |
| Other Authors: | Atkins, Ryan Ng, Wayne Stylli, Stanley Kaye, Andrew |
| Keywords: | Australian Prostate Cancer Research Centre at Epworth, Richmond, VIC, Australia. Glioblastoma Multiforme GBM Glial Brain Tumour Base Excision Repair Glioma Resistance MGMT PARP Temozolomide Chemotherapy |
| Issue Date: | Jan-2015 |
| Publisher: | Elsevier |
| Citation: | J Clin Neurosci. 2015 Jan;22(1):14-20 |
| Abstract: | Glioblastoma multiforme (GBM) is a malignant and incurable glial brain tumour. The current best treatment for GBM includes maximal safe surgical resection followed by concomitant radiotherapy and adjuvant temozolomide. Despite this, median survival is still only 14-16 months. Mechanisms that lead to chemo- and radio-resistance underpin treatment failure. Insights into the DNA repair mechanisms that permit resistance to chemoradiotherapy in GBM may help improve patient responses to currently available therapies. |
| URI: | http://hdl.handle.net/11434/295 |
| URL: | http://www.sciencedirect.com/science/article/pii/S0967586814005670 |
| PubMed URL: | http://www.ncbi.nlm.nih.gov/pubmed/25444993 |
| ISSN: | 0967-5868 |
| Journal Title: | Journal of Clinical Neuroscience |
| Type: | Journal Article |
| Affiliated Organisations: | Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital, Grattan Street, Parkville, VIC 3050, Australia Department of Neurosurgery, The Royal Melbourne Hospital, Parkville, VIC, Australia. |
| Appears in Collections: | Cancer Services Epworth Prostate Centre Neurosciences |
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