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http://hdl.handle.net/11434/2247| Title: | Plasma mass spectrometry-based proteomic biomarker discovery for endometriosis. |
| Epworth Authors: | Holdsworth-Carson, Sarah |
| Other Authors: | Rao, Sushma Boughton, Berin Snel, Marten Pukala, Tara Griffiths, Meaghan Rogers, Peter Girling, Jane |
| Keywords: | Endometriosis Mass Spectrometry MS Proteomic Biomarker Plasma Plasma Proteins . Julia Argyrou Endometriosis Centre, Epworth HealthCare, Victoria, Australia |
| Issue Date: | Oct-2023 |
| Conference Name: | Epworth HealthCare Research Month 2023 |
| Conference Location: | Epworth Research Institute, Victoria, Australia |
| Abstract: | Background and Aim: Endometriosis diagnosis requires surgical visualisation of lesions and histopathology. To date, no non-invasive diagnostic test has been validated. Discovery research using sensitive high-throughput mass spectrometry (MS) has the potential to improve identification of clinically-relevant plasma proteins.The aim of this study was to undertake MS-based proteomic biomarker discovery using minimally-invasive plasma specimens from patients with and without endometriosis.Conclusions: High-throughput MS-based proteomic biomarker discovery successfully identified 470 proteins in an endometriosis cohort. Case-control analysis revealed significantly different protein expression profiles in association with endometriosis. Further validation in an independent sample set is underway. Biomarker discovery using plasma proteomics offers a minimally invasive approach to endometriosis diagnosis. |
| URI: | http://hdl.handle.net/11434/2247 |
| Type: | Conference Poster |
| Affiliated Organisations: | South Australian Health and Medical Research Institute, Adelaide, SA, Australia Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia Australian National Phenome Centre, Harry Perkins Institute of Medical Research, Murdoch, WA, Australia School of Physical Sciences, University of Adelaide, Adelaide, SA, Australia Department of Obstetrics and Gynaecology, University of Melbourne and Gynaecology Research Centre, Royal Women’s Hospital, Parkville, VIC, Australia Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand |
| Type of Clinical Study or Trial: | Case Control Studies |
| Appears in Collections: | Research Week |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| JAECE Research Poster Human Plasma Study (Nov22)_SCarson.pdf | 482.96 kB | Adobe PDF |  View/Open |
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